UPF2

Across TCGA cell cohorts, UPF2 mutation is significantly associated with the RNA expression of many other genes, with 530 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UPF2-associated genes across cancer lineages are FAM160A1, GAGE12J, and TBL1Y. Each is linked with UPF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UPF2-to-partner and partner-to-UPF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM160A1 grouped by UPF2-low versus UPF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPF2→partner) and Y-score (partner→UPF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM160A1 →	+0.771	+3.212	.006	.006	3	2
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	1
SOFT_TISSUE	H2BC1 →	+0.433	+5.977	<.001	.001	3	1
SOFT_TISSUE	H2AC1 →	+0.193	+5.977	<.001	.001	3	1
SOFT_TISSUE	KRT6C →	+0.013	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 530 associations by consensus.

FAM160A1 by UPF2 expression — LARGE_INTESTINE

Explore this box plot interactively →