UNG

Across TCGA pan-cancer cohorts, UNG mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UNG data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher UNG mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UNG expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where UNG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.383	0.779	<.001	36	view →
LSCC	DFS	Tertile	II,III,IV	0.879	0.544	.008	27	view →
LUAD	DFS	Quartile	All	0.482	1.000	.028	4	view →
HNSC	OS	Median	III,IV	0.946	1.000	.037	1	view →
GBM	DFS	Median	All	0.405	0.227	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UNG–CCRCC (DFS)

Open the CCRCC breakdown →