UNG

Across TCGA pan-cancer cohorts, UNG RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of UNG’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where UNG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UNG is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

BLCA, THCA, and HNSC are the cancer types where UNG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UNG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+1.555	<.001	11	view →
THCA	Male	III,IV	−1.022	<.001	10	view →
HNSC	Male	III,IV	+0.800	<.001	10	view →
LUAD	Male	III,IV	+1.416	<.001	9	view →
LUSC	Female	All	+1.882	<.001	8	view →
LIHC	Male	All	+0.851	<.001	8	view →
COAD	Female	All	+0.602	<.001	7	view →
KIRP	All	III,IV	+0.527	.006	7	view →
UCEC	All	III,IV	+1.087	.001	6	view →
STAD	Male	II,III,IV	+1.031	<.001	6	view →
KICH	Male	All	−0.718	<.001	6	view →
BRCA	All	III,IV	+0.498	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

UNG–BLCA

Open the BLCA breakdown →