UNG

Across TCGA patient cohorts, UNG mutation is significantly associated with the RNA expression of many other genes, with 758 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNG-associated genes across cancer lineages are ATP6V1E1P2, OR4X7P, and MIR4264. Each is linked with UNG in more than 1 cancer types. Because this analysis shows association rather than direction, both UNG-to-partner and partner-to-UNG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP6V1E1P2 grouped by UNG-low versus UNG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNG→partner) and Y-score (partner→UNG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP6V1E1P2 →	+0.214	+2.398	<.001	.007	3	2
STAD	OR4X7P →	+0.291	+4.798	<.001	.006	3	2
STAD	MIR4264 →	+0.455	+4.678	<.001	.007	3	2
STAD	MRPL57P1 →	+0.144	+4.678	<.001	.007	3	2
UCEC	MTHFD2P5 →	+0.140	+2.443	<.001	.002	3	2
UCEC	RNA5SP419 →	+0.886	+2.398	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 758 associations by consensus.

ATP6V1E1P2 by UNG expression — UCEC

Explore this box plot interactively →