UNG

Across TCGA patient cohorts, UNG mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNG-associated genes across cancer lineages are eEF2, EGFR_pY1068, and ER-alpha. Each is linked with UNG in more than 1 cancer types. Because this analysis shows association rather than direction, both UNG-to-partner and partner-to-UNG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by UNG-low versus UNG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNG→partner) and Y-score (partner→UNG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.550	+3.169	.005	.020	3	1
UCEC	EGFR_pY1068 →	-0.306	-3.000	.026	.036	3	1
UCEC	ER-alpha →	-1.203	-3.169	.007	.020	3	1
UCEC	FASN →	+0.485	+3.169	.025	.020	3	1
UCEC	ACC1 →	+0.500	+2.820	.012	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.204	-3.156	.027	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eEF2 by UNG expression — UCEC

Explore this box plot interactively →