UNCX

Across TCGA pan-cancer cohorts, UNCX Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated UNCX data layer compared with 15 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher UNCX Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UNCX expression acts as an unfavorable survival marker, although some lineages such as SCLC show a favorable association.

COAD, BRCA, and SCLC are the cancer types where UNCX Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.168	0.806	.002	24	view →
BRCA	OS	Median	All	0.306	0.924	<.001	12	view →
SCLC	DFS	Median	II,III,IV	1.000	0.303	.027	6	view →
LGG	OS	Median	All	0.415	0.811	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

UNCX–COAD (OS)

Open the COAD breakdown →