UNCX

Across TCGA pan-cancer cohorts, UNCX RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of UNCX’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where UNCX RNA is repressed in tumor relative to normal tissue. In most cancer types UNCX is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where UNCX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UNCX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.411	<.001	12	view →
KICH	Female	II,III,IV	−2.205	<.001	10	view →
KIRP	Male	All	−1.406	<.001	9	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

UNCX–KIRC

Open the KIRC breakdown →