UNCX

Across TCGA patient cohorts, UNCX RNA expression is significantly associated with the go_rna of many other GO terms, with 5,295 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible UNCX-associated GO terms across cancer lineages are Non-canonical Wnt signaling pathway, Mitochondrial gene expression, and Amino acid activation. Each is linked with UNCX in more than 8 cancer types. Because this analysis shows association rather than direction, both UNCX-to-partner and partner-to-UNCX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Non-canonical Wnt signaling pathway grouped by UNCX-low versus UNCX-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UNCX→partner) and Y-score (partner→UNCX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Non-canonical Wnt signaling pathway →	+0.064	+0.761	<.001	<.001	3	9
ESCA	Mitochondrial gene expression →	+0.069	+0.043	<.001	.002	3	9
ESCA	Amino acid activation →	+0.063	+0.052	<.001	<.001	3	7
ESCA	Negative regulation of mitotic cell cycle →	+0.056	+0.044	.001	.001	3	7
TGCT	Cytoplasmic sequestering of NF-kappaB →	+0.090	+0.835	<.001	<.001	3	7
ESCA	Establishment of protein localization to mitochondrial membrane →	+0.063	+0.041	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,295 associations by consensus.

Non-canonical Wnt signaling pathway by UNCX expression — TGCT

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