UNCX

Across TCGA patient cohorts, UNCX protein abundance is significantly associated with the RNA expression of many other genes, with 707 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible UNCX-associated genes across cancer lineages are DEPDC5, DIDO1, and SUV39H1. Each is linked with UNCX in more than 1 cancer types. Because this analysis shows association rather than direction, both UNCX-to-partner and partner-to-UNCX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, UNCX versus DEPDC5 in PDAC, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNCX→partner) and Y-score (partner→UNCX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	DEPDC5 →	-0.264	-0.539	<.001	.009	3	1
PDAC	DIDO1 →	-0.337	-0.575	.004	<.001	3	1
PDAC	SUV39H1 →	-0.432	-0.611	.003	.003	3	1
PDAC	MTMR8 →	-0.506	-0.659	<.001	<.001	3	1
PDAC	GGA2 →	-0.263	-0.600	.003	.002	3	1
PDAC	FKTN →	-0.336	-0.622	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 707 associations by consensus.

UNCX vs DEPDC5 — PDAC

Explore this scatter interactively →