UNCX

Across TCGA cell cohorts, UNCX RNA expression is significantly associated with the go_rna of many other GO terms, with 738 significant associations in total. BONE shows the largest number of these associations.

The most reproducible UNCX-associated GO terms across cancer lineages are Regulation of DNA repair, RNA export from nucleus, and Negative regulation of RNA catabolic process. Each is linked with UNCX in more than 3 cancer types. Because this analysis shows association rather than direction, both UNCX-to-partner and partner-to-UNCX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by UNCX-low versus UNCX-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UNCX→partner) and Y-score (partner→UNCX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of DNA repair →	+0.068	+0.885	<.001	.003	3	4
BONE	RNA export from nucleus →	+0.101	+1.430	.005	.007	3	4
BONE	Negative regulation of RNA catabolic process →	+0.068	+1.380	<.001	.008	3	4
BONE	Positive regulation of double-strand break repair →	+0.085	+1.256	<.001	.002	3	4
BONE	Positive regulation of DNA metabolic process →	+0.078	+0.876	<.001	.004	3	4
BONE	Protein insertion into mitochondrial membrane →	+0.080	+0.891	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 738 associations by consensus.

Regulation of DNA repair by UNCX expression — BONE

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