UNCX

Across TCGA cell cohorts, UNCX mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UNCX-associated genes across cancer lineages are ZNF831, TAFA1, and CENPVL1. Each is linked with UNCX in more than 1 cancer types. Because this analysis shows association rather than direction, both UNCX-to-partner and partner-to-UNCX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF831 grouped by UNCX-low versus UNCX-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNCX→partner) and Y-score (partner→UNCX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CENPVL1 →	+0.227	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ZNF831 by UNCX expression — LARGE_INTESTINE

Explore this box plot interactively →