UNC93B1

Across TCGA patient cohorts, UNC93B1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC93B1-associated genes across cancer lineages are LKB1, NF2, and PCNA. Each is linked with UNC93B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UNC93B1-to-partner and partner-to-UNC93B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LKB1 grouped by UNC93B1-low versus UNC93B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC93B1→partner) and Y-score (partner→UNC93B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LKB1 →	-0.111	-3.169	.025	.019	3	1
UCEC	NF2 →	+0.313	+3.169	.001	.018	3	1
UCEC	PCNA →	+0.214	+2.584	.033	.011	3	1
UCEC	Annexin-1 →	+0.821	+3.341	<.001	.005	3	1
UCEC	Caspase-8 →	-0.300	-3.459	.010	.005	3	1
UCEC	Chk2_pT68 →	-0.181	-2.312	.036	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

LKB1 by UNC93B1 expression — UCEC

Explore this box plot interactively →