UNC93B1

Across TCGA pan-cancer cohorts, UNC93B1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated UNC93B1 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher UNC93B1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UNC93B1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

ACC, BLCA, and LGG are the cancer types where UNC93B1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.236	0.694	.001	84	view →
BLCA	DFS	Quartile	All	0.635	0.423	<.001	68	view →
LGG	DFS	Median	All	0.291	0.498	<.001	53	view →
PAAD	DFS	Median	All	0.241	0.500	<.001	49	view →
LAML	DFS	Median	All	0.255	0.503	<.001	40	view →
BRCA	OS	Quartile	All	0.474	0.673	.008	35	view →
KIRP	DFS	Median	IV	0.039	0.526	.027	30	view →
ESCA	OS	Median	IV	0.222	0.698	.006	27	view →
SKCM	OS	Median	All	0.824	0.739	.010	26	view →
LUSC	DFS	Quartile	All	0.268	0.502	.001	23	view →
KICH	DFS	Quartile	II,III,IV	0.665	1.000	.027	22	view →
UVM	OS	Tertile	All	0.393	0.689	.013	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

UNC93B1–ACC (DFS)

Open the ACC breakdown →