UNC93A

Across TCGA patient cohorts, UNC93A mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC93A-associated genes across cancer lineages are ACC1, C-Raf, and FOXO3a_pS318_S321. Each is linked with UNC93A in more than 2 cancer types. Because this analysis shows association rather than direction, both UNC93A-to-partner and partner-to-UNC93A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by UNC93A-low versus UNC93A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC93A→partner) and Y-score (partner→UNC93A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ACC1 →	+0.390	+3.597	.003	.001	3	3
UCEC	C-Raf →	+0.220	+2.906	<.001	.001	3	3
UCEC	FOXO3a_pS318_S321 →	-0.135	-2.575	.002	.001	3	2
UCEC	mTOR_pS2448 →	-0.150	-2.687	.004	.005	3	2
UCEC	STAT3_pY705 →	-0.405	-2.321	<.001	.005	3	2
UCEC	VHL →	-0.893	-2.584	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

ACC1 by UNC93A expression — SKCM

Explore this box plot interactively →