UNC93A

Across TCGA cell cohorts, UNC93A mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UNC93A-associated genes across cancer lineages are OR6B1, MUC22, and SIGLEC8. Each is linked with UNC93A in more than 1 cancer types. Because this analysis shows association rather than direction, both UNC93A-to-partner and partner-to-UNC93A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6B1 grouped by UNC93A-low versus UNC93A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC93A→partner) and Y-score (partner→UNC93A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR6B1 →	+0.012	+5.643	<.001	.002	3	2
BLOOD_Leukemia	MUC22 →	+0.005	+5.569	<.001	.001	3	2
KIDNEY	SIGLEC8 →	+0.033	+5.000	<.001	.005	3	1
KIDNEY	DEFB108B →	+0.080	+5.000	<.001	.005	3	1
CNS	GATA5 →	+0.426	+2.933	.001	.008	3	1
CNS	GKN2 →	+0.150	+3.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

OR6B1 by UNC93A expression — BLOOD_Lymphoma

Explore this box plot interactively →