UNC5CL

Across TCGA pan-cancer cohorts, UNC5CL Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated UNC5CL data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher UNC5CL Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UNC5CL expression acts as an unfavorable survival marker.

KIRP, ACC, and STAD are the cancer types where UNC5CL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.157	0.704	.005	12	view →
ACC	OS	Median	All	0.188	0.820	<.001	12	view →
STAD	OS	Median	II,III,IV	0.247	0.662	.007	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LGG	OS	Median	All	0.291	0.799	.004	3	view →
BLCA	DFS	Median	III,IV	0.212	0.574	.047	3	view →
LUAD	OS	Median	All	0.188	0.670	.049	3	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

UNC5CL–KIRP (OS)

Open the KIRP breakdown →