UNC5CL

Across TCGA pan-cancer cohorts, UNC5CL RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of UNC5CL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UNC5CL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UNC5CL is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KICH, and THCA are the cancer types where UNC5CL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UNC5CL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.519	<.001	12	view →
KICH	All	IV	−4.165	<.001	11	view →
THCA	All	IV	+2.692	<.001	11	view →
COAD	Male	II,III,IV	+2.022	<.001	11	view →
LUAD	Female	III,IV	+2.302	<.001	9	view →
READ	Female	All	+2.142	<.001	5	view →
CHOL	All	All	+2.254	<.001	2	view →
BRCA	All	IV	+0.550	.044	2	view →
BLCA	All	All	+0.461	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

UNC5CL–HNSC

Open the HNSC breakdown →