UNC5CL

Across TCGA pan-cancer cohorts, UNC5CL mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated UNC5CL data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher UNC5CL mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UNC5CL expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where UNC5CL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.474	1.000	.006	20	view →
CCRCC	OS	Median	All	1.000	0.886	.002	18	view →
PDAC	DFS	Tertile	All	0.555	0.863	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

UNC5CL–LUAD (OS)

Open the LUAD breakdown →