UNC5CL

Across TCGA patient cohorts, UNC5CL mutation is significantly associated with the RNA expression of many other genes, with 1,077 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC5CL-associated genes across cancer lineages are MFAP1, COPS3, and WRAP53. Each is linked with UNC5CL in more than 2 cancer types. Because this analysis shows association rather than direction, both UNC5CL-to-partner and partner-to-UNC5CL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MFAP1 grouped by UNC5CL-low versus UNC5CL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC5CL→partner) and Y-score (partner→UNC5CL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MFAP1 →	+0.638	+2.917	<.001	.001	3	3
UCEC	COPS3 →	+0.528	+2.906	.001	.002	3	3
COAD	WRAP53 →	+0.463	+3.479	<.001	.002	3	3
UCEC	RAD51 →	+0.714	+2.917	.002	.001	3	3
UCEC	MSANTD3 →	+0.541	+3.502	.003	.002	3	3
SKCM	PHF5A →	+0.558	+3.214	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,077 associations by consensus.

MFAP1 by UNC5CL expression — UCEC

Explore this box plot interactively →