UNC5CL

Across TCGA patient cohorts, UNC5CL mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC5CL-associated genes across cancer lineages are Smad4, Caspase-7-cleavedD198, and Annexin-1. Each is linked with UNC5CL in more than 1 cancer types. Because this analysis shows association rather than direction, both UNC5CL-to-partner and partner-to-UNC5CL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad4 grouped by UNC5CL-low versus UNC5CL-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC5CL→partner) and Y-score (partner→UNC5CL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Smad4 →	+0.129	+3.321	.024	.009	3	2
COAD	Caspase-7-cleavedD198 →	+1.554	+3.186	<.001	.009	3	2
UCEC	Annexin-1 →	+0.765	+3.479	.001	.002	3	2
UCEC	ATM →	-0.727	-3.807	<.001	<.001	3	2
UCEC	c-Met_pY1235 →	+0.072	+2.700	.031	.006	3	2
COAD	INPP4B →	-0.443	-2.321	.006	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Smad4 by UNC5CL expression — COAD

Explore this box plot interactively →