UNC5CL

Across TCGA cell cohorts, UNC5CL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,209 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UNC5CL-associated GO terms across cancer lineages are Regulation of myoblast fusion, Regulation of syncytium formation by plasma membrane fusion, and Negative regulation of Arp2/3 complex-mediated actin nucleation. Each is linked with UNC5CL in more than 12 cancer types. Because this analysis shows association rather than direction, both UNC5CL-to-partner and partner-to-UNC5CL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by UNC5CL-low versus UNC5CL-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC5CL→partner) and Y-score (partner→UNC5CL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.110	+0.697	.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.093	+0.693	.003	<.001	3	11
CNS	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.136	+0.371	<.001	<.001	3	9
STOMACH	Actin filament-based transport →	+0.156	+1.272	<.001	.006	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.105	+0.570	.004	.003	3	8
PANCREAS	Protein transport into membrane raft →	+0.255	+0.723	.009	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,209 associations by consensus.

Regulation of myoblast fusion by UNC5CL expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →