UNC5CL

Across TCGA cell cohorts, UNC5CL mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible UNC5CL-associated genes across cancer lineages are AIPL1, OR4X2, and MAGEB10. Each is linked with UNC5CL in more than 1 cancer types. Because this analysis shows association rather than direction, both UNC5CL-to-partner and partner-to-UNC5CL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AIPL1 grouped by UNC5CL-low versus UNC5CL-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC5CL→partner) and Y-score (partner→UNC5CL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	AIPL1 →	+0.195	+3.597	.009	.006	3	1
SOFT_TISSUE	OR4X2 →	+0.021	+4.369	<.001	<.001	3	1
SOFT_TISSUE	MAGEB10 →	+0.438	+3.637	<.001	.002	3	1
SOFT_TISSUE	OR6B2 →	+0.042	+3.142	<.001	.008	3	1
SOFT_TISSUE	OR56A4 →	+0.008	+3.977	<.001	.007	3	1
SOFT_TISSUE	PRR20B →	+0.021	+3.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

AIPL1 by UNC5CL expression — SOFT_TISSUE

Explore this box plot interactively →