UNC5C

Across TCGA pan-cancer cohorts, UNC5C Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated UNC5C data layer compared with 23 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher UNC5C Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated UNC5C expression acts as an unfavorable survival marker.

BRCA, SCLC, and LGG are the cancer types where UNC5C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	III,IV	0.093	0.880	<.001	20	view →
SCLC	OS	Median	All	0.140	0.853	<.001	15	view →
LGG	DFS	Median	All	0.230	0.753	.005	12	view →
KIRC	OS	Median	All	0.172	0.811	.002	12	view →
LUAD	DFS	Median	IV	0.045	0.717	<.001	12	view →
LUSC	OS	Median	All	0.389	0.733	.007	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
HNSC	DFS	Median	III,IV	0.176	0.504	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

UNC5C–BRCA (DFS)

Open the BRCA breakdown →