UNC5B

Across TCGA patient cohorts, UNC5B mutation is significantly associated with the RNA expression of many other genes, with 5,104 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC5B-associated genes across cancer lineages are SKA2, CAMK1D, and ZBTB21. Each is linked with UNC5B in more than 2 cancer types. Because this analysis shows association rather than direction, both UNC5B-to-partner and partner-to-UNC5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA2 grouped by UNC5B-low versus UNC5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC5B→partner) and Y-score (partner→UNC5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA2 →	+0.565	+2.157	<.001	<.001	3	3
COAD	CAMK1D →	-1.063	-2.308	<.001	.006	3	3
SKCM	ZBTB21 →	+0.509	+2.247	.002	.005	3	3
UCEC	LINC00449 →	+0.220	+1.485	.001	.003	3	3
SKCM	BCL2L13 →	+0.371	+1.880	.003	.001	3	3
LUAD	ADAM10 →	+0.505	+3.333	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,104 associations by consensus.

SKA2 by UNC5B expression — UCEC

Explore this box plot interactively →