UNC5B

Across TCGA pan-cancer cohorts, UNC5B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated UNC5B data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher UNC5B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UNC5B expression acts as an unfavorable survival marker, although some lineages such as KIRC and DLBC show a favorable association.

KIRP, OV, and LIHC are the cancer types where UNC5B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.318	0.673	<.001	95	view →
OV	OS	Tertile	III,IV	0.246	0.359	.002	64	view →
LIHC	OS	Tertile	All	0.568	0.762	<.001	57	view →
KIRC	OS	Tertile	All	0.752	0.578	.001	52	view →
MESO	OS	Median	All	0.273	0.505	<.001	45	view →
LGG	OS	Tertile	All	0.821	0.933	<.001	32	view →
DLBC	DFS	Median	III,IV	1.000	0.457	.003	29	view →
KICH	OS	Quartile	III,IV	0.237	1.000	.010	28	view →
ACC	DFS	Quartile	II,III,IV	0.105	0.516	.001	20	view →
THCA	DFS	Tertile	II,III,IV	0.652	0.948	.006	19	view →
SARC	OS	Median	All	0.619	0.822	.001	17	view →
ESCA	DFS	Median	II,III,IV	0.387	0.574	.007	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

UNC5B–KIRP (DFS)

Open the KIRP breakdown →