UNC5B

Across TCGA cell cohorts, UNC5B mutation is significantly associated with the RNA expression of many other genes, with 110 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UNC5B-associated genes across cancer lineages are IQCF5, UGT2B10, and GOLGA6L6. Each is linked with UNC5B in more than 1 cancer types. Because this analysis shows association rather than direction, both UNC5B-to-partner and partner-to-UNC5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by UNC5B-low versus UNC5B-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC5B→partner) and Y-score (partner→UNC5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.056	+5.357	<.001	.003	3	2
PANCREAS	UGT2B10 →	+0.402	+5.000	<.001	.006	3	1
SOFT_TISSUE	GOLGA6L6 →	+0.013	+5.369	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	MRAP →	+0.028	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	HTN3 →	+0.079	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	SLC5A8 →	+0.012	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 110 associations by consensus.

IQCF5 by UNC5B expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →