UNC5B-AS1

Across TCGA pan-cancer cohorts, UNC5B-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated UNC5B-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher UNC5B-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UNC5B-AS1 expression acts as an unfavorable survival marker, although some lineages such as CESC and STAD show a favorable association.

UVM, KIRC, and CESC are the cancer types where UNC5B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	All	0.763	1.000	<.001	107	view →
KIRC	DFS	Median	All	0.488	0.733	<.001	80	view →
CESC	OS	Tertile	All	0.950	0.819	.003	56	view →
GBM	DFS	Median	All	0.181	0.320	<.001	47	view →
PAAD	OS	Median	All	0.480	0.693	.005	37	view →
LGG	DFS	Median	All	0.318	0.526	<.001	35	view →
LIHC	OS	Quartile	All	0.378	0.664	<.001	26	view →
STAD	OS	Tertile	III,IV	0.741	0.290	.001	15	view →
MESO	OS	Median	III,IV	0.305	0.467	.017	12	view →
SKCM	OS	Tertile	IV	1.000	0.194	.003	12	view →
TGCT	DFS	Median	All	0.743	0.919	.007	12	view →
THCA	DFS	Median	All	0.948	0.867	.008	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

UNC5B-AS1–UVM (OS)

Open the UVM breakdown →