UNC5B-AS1

Across TCGA pan-cancer cohorts, UNC5B-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of UNC5B-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where UNC5B-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UNC5B-AS1 is over-expressed in tumor, although a few such as STAD and PRAD show the opposite, repressed pattern.

THCA, STAD, and KICH are the cancer types where UNC5B-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UNC5B-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+2.362	<.001	11	view →
STAD	All	II,III,IV	−1.215	<.001	9	view →
KICH	All	II,III,IV	+1.520	<.001	8	view →
KIRC	Male	All	+0.358	<.001	8	view →
COAD	All	All	+0.739	.001	7	view →
BRCA	All	III,IV	+0.691	<.001	6	view →
CHOL	All	All	+0.834	.001	5	view →
LIHC	All	All	+0.187	<.001	5	view →
LUSC	Female	All	+1.231	<.001	4	view →
PAAD	All	All	+2.210	.007	2	view →
HNSC	Male	III,IV	+1.403	.005	2	view →
PRAD	All	All	−0.908	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

UNC5B-AS1–THCA

Open the THCA breakdown →