UNC5A

Across TCGA cell cohorts, UNC5A mutation is significantly associated with the RNA expression of many other genes, with 428 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UNC5A-associated genes across cancer lineages are HAO1, NUP88, and SENP3. Each is linked with UNC5A in more than 1 cancer types. Because this analysis shows association rather than direction, both UNC5A-to-partner and partner-to-UNC5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAO1 grouped by UNC5A-low versus UNC5A-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC5A→partner) and Y-score (partner→UNC5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HAO1 →	+0.271	+4.011	<.001	.009	3	2
LARGE_INTESTINE	NUP88 →	+0.551	+3.082	<.001	.007	3	2
LARGE_INTESTINE	SENP3 →	+0.535	+2.743	<.001	.001	3	2
LARGE_INTESTINE	COX10 →	+0.580	+3.649	.001	<.001	3	2
LUNG_NSCLC_LUSC	NPVF →	+0.029	+4.108	.002	.005	3	1
LUNG_NSCLC_LUSC	MC3R →	+0.446	+4.108	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 428 associations by consensus.

HAO1 by UNC5A expression — PANCREAS

Explore this box plot interactively →