UNC45A

Across TCGA patient cohorts, UNC45A mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC45A-associated genes across cancer lineages are STAT3_pY705, EGFR_pY1068, and PCNA. Each is linked with UNC45A in more than 2 cancer types. Because this analysis shows association rather than direction, both UNC45A-to-partner and partner-to-UNC45A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by UNC45A-low versus UNC45A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC45A→partner) and Y-score (partner→UNC45A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.296	-1.807	.001	.024	3	3
UCEC	EGFR_pY1068 →	-0.184	-1.440	.034	.024	3	2
UCEC	PCNA →	+0.151	+1.874	.044	.049	3	2
UCEC	VHL →	-0.757	-1.415	.001	.043	3	2
UCEC	Cyclin-B1 →	+0.421	+1.440	.030	.024	3	2
UCEC	ERK2 →	+0.176	+2.415	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

STAT3_pY705 by UNC45A expression — UCEC

Explore this box plot interactively →