UNC13C

Across TCGA patient cohorts, UNC13C RNA expression is significantly associated with the protein abundance of many other proteins, with 16,184 significant associations in total. GBM shows the largest number of these associations.

The most reproducible UNC13C-associated proteins across cancer lineages are FOSL2_S120, ANK2, and SPTBN1_S2128. Each is linked with UNC13C in more than 3 cancer types. Because this analysis shows association rather than direction, both UNC13C-to-partner and partner-to-UNC13C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, UNC13C versus FOSL2_S120 in GBM, with a Pearson correlation of -0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC13C→partner) and Y-score (partner→UNC13C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FOSL2_S120 →	-0.626	-1.095	<.001	<.001	3	4
GBM	ANK2 →	+0.518	+1.331	<.001	<.001	3	4
BRCA	SPTBN1_S2128 →	+0.654	+0.039	<.001	.001	3	3
GBM	EIF3B →	-0.157	-0.984	<.001	<.001	3	3
COAD	ELN →	+0.652	+0.014	.001	.005	3	3
BRCA	AKAP12_T1116 →	+0.904	+0.030	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,184 associations by consensus.

UNC13C vs FOSL2_S120 — GBM

Explore this scatter interactively →