UNC13C

Across TCGA pan-cancer cohorts, UNC13C RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated UNC13C data layer compared with 13 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher UNC13C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UNC13C expression acts as an unfavorable survival marker, although some lineages such as UCS and ACC show a favorable association.

KIRP, UCS, and THYM are the cancer types where UNC13C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.478	0.814	.001	43	view →
UCS	DFS	Quartile	II,III,IV	0.683	0.179	.004	42	view →
THYM	DFS	Tertile	II,III,IV	0.686	0.967	<.001	41	view →
ACC	DFS	Quartile	All	0.838	0.245	.001	39	view →
LIHC	OS	Quartile	III,IV	0.334	0.662	.001	28	view →
LUAD	DFS	Median	IV	0.777	0.212	.001	27	view →
BLCA	OS	Tertile	IV	0.364	0.588	.008	27	view →
CHOL	DFS	Median	II,III,IV	0.802	0.137	.010	27	view →
SKCM	DFS	Tertile	IV	1.000	0.247	.007	17	view →
SCLC	OS	Median	III,IV	0.554	0.293	.023	10	view →
DLBC	OS	Quartile	II,III,IV	0.522	1.000	.034	9	view →
KICH	OS	Tertile	All	0.938	0.578	.029	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

UNC13C–KIRP (DFS)

Open the KIRP breakdown →