UNC13C

Across TCGA patient cohorts, UNC13C mutation is significantly associated with the RNA expression of many other genes, with 7,238 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC13C-associated genes across cancer lineages are PGAM5, PBK, and MASTL. Each is linked with UNC13C in more than 5 cancer types. Because this analysis shows association rather than direction, both UNC13C-to-partner and partner-to-UNC13C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGAM5 grouped by UNC13C-low versus UNC13C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC13C→partner) and Y-score (partner→UNC13C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGAM5 →	+0.475	+1.384	<.001	<.001	3	6
LUAD	PBK →	+0.817	+1.847	<.001	.007	3	6
SKCM	MASTL →	+0.351	+1.040	<.001	<.001	3	6
UCEC	CDCA2 →	+0.762	+1.497	<.001	<.001	3	5
UCEC	WDHD1 →	+0.595	+1.297	<.001	<.001	3	5
UCEC	LINC00092 →	-0.383	-1.382	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,238 associations by consensus.

PGAM5 by UNC13C expression — UCEC

Explore this box plot interactively →