UNC13C

Across TCGA cell cohorts, UNC13C RNA expression is significantly associated with the go_rna of many other GO terms, with 700 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UNC13C-associated GO terms across cancer lineages are Negative regulation of epithelial cell differentiation involved in kidney development, Positive regulation of establishment of T cell polarity, and Regulation of tumor necrosis factor (ligand) superfamily member 11 production. Each is linked with UNC13C in more than 3 cancer types. Because this analysis shows association rather than direction, both UNC13C-to-partner and partner-to-UNC13C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of epithelial cell differentiation involved in kidney development grouped by UNC13C-low versus UNC13C-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC13C→partner) and Y-score (partner→UNC13C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of epithelial cell differentiation involved in kidney development →	+0.145	+1.224	<.001	.004	3	4
BLOOD_Myeloma	Positive regulation of establishment of T cell polarity →	-0.096	-2.485	.002	<.001	3	3
BLOOD_Leukemia	Regulation of tumor necrosis factor (ligand) superfamily member 11 production →	+0.787	+1.279	<.001	.002	3	3
BLOOD_Myeloma	Regulation of pre-miRNA processing →	-0.088	-2.651	.004	.002	3	3
LIVER	Regulation of neurotrophin production →	-1.424	-0.936	<.001	.009	3	3
LIVER	Motor neuron apoptotic process →	+0.220	+0.711	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 700 associations by consensus.

Negative regulation of epithelial cell differentiation involved in kidney development by UNC13C expression — BLOOD_Leukemia

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