UNC13C

Across TCGA cell cohorts, UNC13C mutation is significantly associated with the RNA expression of many other genes, with 805 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UNC13C-associated genes across cancer lineages are CYB5D1, GPR63, and SCO1. Each is linked with UNC13C in more than 2 cancer types. Because this analysis shows association rather than direction, both UNC13C-to-partner and partner-to-UNC13C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYB5D1 grouped by UNC13C-low versus UNC13C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC13C→partner) and Y-score (partner→UNC13C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CYB5D1 →	+1.042	+2.043	<.001	<.001	3	3
LARGE_INTESTINE	GPR63 →	+0.732	+1.706	<.001	<.001	3	3
LARGE_INTESTINE	SCO1 →	+0.590	+2.700	<.001	<.001	3	3
LARGE_INTESTINE	POLR1E →	+0.420	+1.706	.004	<.001	3	3
LARGE_INTESTINE	KLRG1 →	+0.474	+1.706	.004	<.001	3	3
BREAST	PRPSAP2 →	+0.662	+3.152	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 805 associations by consensus.

CYB5D1 by UNC13C expression — LARGE_INTESTINE

Explore this box plot interactively →