UNC13C

Across TCGA cell cohorts, UNC13C mutation is significantly associated with the mutation status of many other genes, with 5,273 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UNC13C-associated genes across cancer lineages are RYR3, GLI2, and ADAMTS19. Each is linked with UNC13C in more than 7 cancer types. Because this analysis shows association rather than direction, both UNC13C-to-partner and partner-to-UNC13C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RYR3 grouped by UNC13C-low versus UNC13C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC13C→partner) and Y-score (partner→UNC13C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RYR3 →	+1.525	+1.733	<.001	<.001	1	8
CNS	GLI2 →	+3.277	+3.954	.004	.004	1	8
SOFT_TISSUE	ADAMTS19 →	+5.722	+5.722	<.001	<.001	1	7
SOFT_TISSUE	TNRC18 →	+2.985	+3.562	.008	.008	1	6
OVARY	ALPK2 →	+3.054	+2.465	.001	.001	1	6
SKIN	ABCA12 →	+1.877	+1.877	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,273 associations by consensus.

RYR3 by UNC13C expression — LARGE_INTESTINE

Explore this box plot interactively →