Across TCGA cell cohorts, UNC13B mutation is significantly associated with the RNA expression of many other genes, with 1,467 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UNC13B-associated genes across cancer lineages are SMAD2, C22orf46, and AVP. Each is linked with UNC13B in more than 2 cancer types. Because this analysis shows association rather than direction, both UNC13B-to-partner and partner-to-UNC13B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC13B→partner) and Y-score (partner→UNC13B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SMAD2 →	+0.973	+3.459	<.001	<.001	3	3
LARGE_INTESTINE	C22orf46 →	+1.003	+3.850	<.001	<.001	3	3
SOFT_TISSUE	AVP →	+0.097	+4.977	<.001	.002	3	2
SKIN	KCNK16 →	+0.031	+2.760	<.001	.003	3	2
OVARY	GRIFIN →	+0.035	+5.196	<.001	.005	3	2
LARGE_INTESTINE	RNF125 →	+1.033	+3.850	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,467 associations by consensus.

Exploration

UNC13B survival (RNA) · tumor vs normal (RNA) · all UNC13B data types