UNC13A

Across TCGA pan-cancer cohorts, UNC13A Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated UNC13A data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher UNC13A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UNC13A expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCEC show a favorable association.

THYM, HNSC, and SCLC are the cancer types where UNC13A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
HNSC	OS	Median	II,III,IV	0.051	0.712	<.001	36	view →
SCLC	DFS	Median	All	0.622	0.224	.006	34	view →
THCA	DFS	Median	All	0.070	0.896	<.001	18	view →
LIHC	OS	Median	II,III,IV	0.327	0.777	.013	18	view →
UCEC	DFS	Median	III,IV	0.922	0.523	.018	16	view →
LGG	OS	Median	All	0.663	0.897	.003	5	view →
READ	OS	Median	All	0.652	0.828	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

UNC13A–THYM (OS)

Open the THYM breakdown →