UNC119B

Across TCGA pan-cancer cohorts, UNC119B RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated UNC119B data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher UNC119B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UNC119B expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

LIHC, KIRC, and ACC are the cancer types where UNC119B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.457	0.622	<.001	83	view →
KIRC	DFS	Median	All	0.746	0.526	<.001	78	view →
ACC	DFS	Tertile	All	0.229	0.719	<.001	50	view →
UCS	OS	Median	III,IV	0.550	0.199	.007	44	view →
PAAD	OS	Tertile	All	0.559	0.235	.002	30	view →
STAD	OS	Median	All	0.640	0.477	.003	28	view →
MESO	DFS	Quartile	All	0.217	0.452	<.001	24	view →
LGG	DFS	Tertile	All	0.781	0.875	.011	16	view →
READ	DFS	Median	IV	0.179	0.936	.010	16	view →
LUSC	DFS	Tertile	III,IV	0.262	0.581	.008	15	view →
KIRP	DFS	Median	All	1.000	0.788	.001	14	view →
LUAD	OS	Median	IV	0.337	0.756	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

UNC119B–LIHC (DFS)

Open the LIHC breakdown →