UNC119B

Across TCGA pan-cancer cohorts, UNC119B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of UNC119B’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where UNC119B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UNC119B is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

LIHC, THCA, and LUAD are the cancer types where UNC119B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UNC119B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.950	<.001	9	view →
THCA	Male	III,IV	−1.157	<.001	9	view →
LUAD	Female	III,IV	−1.331	<.001	8	view →
HNSC	Male	All	+0.538	.007	7	view →
BRCA	Female	All	−0.792	<.001	6	view →
CHOL	All	All	+3.235	<.001	5	view →
STAD	All	IV	+0.920	.025	3	view →
COAD	All	All	+0.265	.009	3	view →
UCEC	All	All	−1.258	<.001	2	view →
READ	All	III,IV	+0.850	.034	2	view →
KICH	Male	All	−0.747	.008	2	view →
BLCA	Male	IV	−1.212	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

UNC119B–LIHC

Open the LIHC breakdown →