UNC119B

Across TCGA pan-cancer cohorts, UNC119B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UNC119B data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher UNC119B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UNC119B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

UCEC, CCRCC, and LSCC are the cancer types where UNC119B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.874	1.000	.005	30	view →
CCRCC	DFS	Median	III,IV	0.928	0.128	.014	18	view →
LSCC	DFS	Median	All	0.974	0.904	.005	5	view →
LUAD	DFS	Quartile	II,III,IV	0.822	0.220	.029	4	view →
HNSC	DFS	Median	III,IV	0.882	0.696	.018	3	view →
PDAC	OS	Median	III,IV	0.743	0.435	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UNC119B–UCEC (OS)

Open the UCEC breakdown →