UNC119

Across TCGA pan-cancer cohorts, UNC119 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated UNC119 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UNC119 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UNC119 expression acts as an unfavorable survival marker.

HNSC, BLCA, and UCS are the cancer types where UNC119 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.138	0.710	.001	30	view →
BLCA	OS	Median	III,IV	0.117	0.684	<.001	12	view →
UCS	OS	Median	All	0.153	0.687	.019	6	view →
SKCM	OS	Median	All	0.096	0.323	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

UNC119–HNSC (OS)

Open the HNSC breakdown →