UNC119

Across TCGA pan-cancer cohorts, UNC119 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of UNC119’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UNC119 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UNC119 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where UNC119 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UNC119 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.279	<.001	10	view →
BLCA	All	All	+1.092	<.001	10	view →
COAD	Male	II,III,IV	+0.695	<.001	10	view →
LUAD	Female	All	+0.478	<.001	8	view →
LUSC	Female	All	+1.068	<.001	7	view →
KIRP	All	II,III,IV	+0.433	.006	7	view →
LIHC	Female	II,III,IV	+1.278	<.001	6	view →
STAD	All	II,III,IV	+0.731	<.001	6	view →
KIRC	Male	II,III,IV	−0.727	<.001	6	view →
UCEC	All	All	+0.618	<.001	6	view →
THCA	Male	All	−0.371	<.001	6	view →
BRCA	All	II,III,IV	+0.248	.010	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

UNC119–HNSC

Open the HNSC breakdown →