UNC119

Across TCGA patient cohorts, UNC119 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC119-associated genes across cancer lineages are MSH6, p62 Lck ligand, and STAT3_pY705. Each is linked with UNC119 in more than 1 cancer types. Because this analysis shows association rather than direction, both UNC119-to-partner and partner-to-UNC119 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by UNC119-low versus UNC119-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC119→partner) and Y-score (partner→UNC119) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.373	-2.990	.019	.036	3	1
UCEC	p62 Lck ligand →	+0.409	+2.817	.009	.036	3	1
UCEC	STAT3_pY705 →	-0.386	-3.159	.002	.019	3	1
UCEC	ATM →	-0.947	-3.308	<.001	.009	3	1
UCEC	MEK1 →	+0.435	+3.321	.013	.010	2	1
UCEC	MSH2 →	-0.321	-3.160	.003	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MSH6 by UNC119 expression — UCEC

Explore this box plot interactively →