UMPS

Across TCGA patient cohorts, UMPS mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UMPS-associated genes across cancer lineages are SF2, PARP_cleaved, and Di-Ras3. Each is linked with UMPS in more than 1 cancer types. Because this analysis shows association rather than direction, both UMPS-to-partner and partner-to-UMPS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SF2 grouped by UMPS-low versus UMPS-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UMPS→partner) and Y-score (partner→UMPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SF2 →	+0.157	+3.000	.028	.035	3	2
SKCM	PARP_cleaved →	+0.161	+3.000	.047	.035	3	1
SKCM	Di-Ras3 →	+0.223	+3.012	.002	.018	3	1
UCEC	ERK2 →	+0.241	+2.999	.009	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.122	-3.312	.044	.010	3	1
UCEC	mTOR_pS2448 →	-0.201	-3.156	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

SF2 by UMPS expression — SKCM

Explore this box plot interactively →