UMPS

Across TCGA pan-cancer cohorts, UMPS RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated UMPS data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher UMPS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UMPS expression acts as an unfavorable survival marker, although some lineages such as LUSC and KIRC show a favorable association.

ACC, LIHC, and MESO are the cancer types where UMPS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.188	0.692	<.001	87	view →
LIHC	OS	Tertile	All	0.675	0.843	<.001	73	view →
MESO	DFS	Quartile	All	0.230	0.484	<.001	63	view →
LUSC	DFS	Median	All	0.796	0.697	<.001	62	view →
KICH	DFS	Median	II,III,IV	0.547	0.958	<.001	61	view →
UCEC	DFS	Tertile	All	0.759	0.874	<.001	46	view →
LUAD	DFS	Quartile	All	0.723	0.909	<.001	45	view →
KIRC	DFS	Tertile	All	0.868	0.699	.001	37	view →
READ	OS	Tertile	All	0.853	0.441	.003	29	view →
LGG	OS	Quartile	All	0.668	0.899	<.001	20	view →
SCLC	OS	Median	All	1.000	0.595	.007	16	view →
GBM	DFS	Quartile	All	0.454	0.176	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

UMPS–ACC (DFS)

Open the ACC breakdown →