UMODL1

Across TCGA pan-cancer cohorts, UMODL1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated UMODL1 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UMODL1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated UMODL1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and LUSC show a favorable association.

HNSC, ESCA, and GBM are the cancer types where UMODL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.143	0.665	<.001	18	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	18	view →
GBM	OS	Median	All	0.058	0.416	<.001	6	view →
COAD	DFS	Median	All	0.197	0.696	.026	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
BLCA	DFS	Median	All	1.000	0.465	.047	2	view →
LUSC	DFS	Median	All	0.773	0.374	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

UMODL1–HNSC (DFS)

Open the HNSC breakdown →