ULK2

Across TCGA patient cohorts, ULK2 mutation is significantly associated with the RNA expression of many other genes, with 6,642 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ULK2-associated genes across cancer lineages are FEN1, CNTROB, and AURKB. Each is linked with ULK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ULK2-to-partner and partner-to-ULK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FEN1 grouped by ULK2-low versus ULK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ULK2→partner) and Y-score (partner→ULK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FEN1 →	+0.717	+2.939	<.001	<.001	3	3
SKCM	CNTROB →	+0.415	+2.228	.002	.006	3	3
SKCM	AURKB →	+0.742	+2.925	.001	.001	3	3
SKCM	NUDC →	+0.479	+2.951	<.001	<.001	3	3
UCEC	WDR76 →	+0.874	+2.557	<.001	<.001	3	3
UCEC	CDC45 →	+0.816	+3.422	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,642 associations by consensus.

FEN1 by ULK2 expression — UCEC

Explore this box plot interactively →