ULBP1

Across TCGA patient cohorts, ULBP1 mutation is significantly associated with the RNA expression of many other genes, with 719 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ULBP1-associated genes across cancer lineages are RN7SKP43, RNU4ATAC5P, and RPS6P7. Each is linked with ULBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ULBP1-to-partner and partner-to-ULBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP43 grouped by ULBP1-low versus ULBP1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ULBP1→partner) and Y-score (partner→ULBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SKP43 →	+0.627	+5.151	<.001	.007	3	3
SKCM	RNU4ATAC5P →	+0.485	+5.771	<.001	.003	3	3
SKCM	RPS6P7 →	+0.108	+5.037	<.001	.009	3	3
CESC	RNU1-62P →	+0.200	+4.539	<.001	.008	3	3
CESC	LINC02590 →	+0.176	+4.364	.004	.006	3	2
BRCA	KRTAP8-3P →	+0.257	+6.866	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 719 associations by consensus.

RN7SKP43 by ULBP1 expression — LUSC

Explore this box plot interactively →