UIMC1

Across TCGA patient cohorts, UIMC1 mutation is significantly associated with the RNA expression of many other genes, with 1,706 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UIMC1-associated genes across cancer lineages are CENPNP1, MIR370, and CICP28. Each is linked with UIMC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UIMC1-to-partner and partner-to-UIMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPNP1 grouped by UIMC1-low versus UIMC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UIMC1→partner) and Y-score (partner→UIMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPNP1 →	+0.089	+1.570	<.001	.003	3	3
LUAD	MIR370 →	+0.575	+5.279	<.001	.006	3	2
UCEC	CICP28 →	+0.018	+2.029	<.001	.001	3	2
READ	NPLP1 →	+0.478	+5.421	<.001	.005	3	2
SKCM	RNU6-379P →	+0.277	+2.951	.001	.003	3	2
SKCM	RNA5SP372 →	+0.303	+2.587	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,706 associations by consensus.

CENPNP1 by UIMC1 expression — UCEC

Explore this box plot interactively →